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KMID : 0385520150280020106
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Analytical Science & Technology
2015 Volume.28 No. 2 p.106 ~ p.111
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Alignment change of lipid molecules in lipid bilayers by an antimicrobial peptide protegrin-1
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Kim Chul
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Abstract
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Changes in antimicrobial peptide-lipid mixtures were investigated using 31P solid-state nuclear magnetic resonance spectroscopy. An antimicrobial peptide, protegrin-1, and phosphatidylcholine were deposited on a thin cover glass and incubated under a relative humidity of 95%. The changes in the mixtures were observed after hydration or air-drying. How repetitive hydration and drying changed the phase of the sample was also observed. The degrees of disruption of the well-aligned bilayers of phosphatidylcholine were determined quantitatively by simulating the experimental spectra. The peptide-lipid mixtures changed reversibly after hydration and drying, and the samples reached an equilibrium state after several repetitions.
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KEYWORD
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antimicrobial peptide, protegrin-1, hydration, phase change,
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